(Verse 20) - ''Certain Greeks" - could refer to several things. First, it was the name commonly given to anyone of greek descent, and, more generally came to refer to any and all pagan nations (because they generally spoke greek). They might have been one of three groups:

• Jews who spoke Greek and lived in Greek cities.

• They might have been Greek proselytes.

• They were gentiles and of pagan religion. In this instance (the most likely) they were here to worship Jehovah as one more of their Gods. This was a frequent occurrence. In fact, the outer court of the Temple was called the Court of the Gentiles.

(Verse 21) - The reference to Bethsaida of Galilee was a reference to a worldly city that had a high population of Greeks. It is likely that they chose Philip because he was from Bethsaida and not for any other reason.

"See" here likely contains the idea of conversing with Jesus. They had heard much of Him and desired to hear more. Whether this was for genuinely spiritual reasons or not is unknown. It does seem unlikely that Jesus would refuse any genuine seeker; primarily because they would not be genuinely seeking unless the Spirit of God was drawing them. Were this the case, Jesus would certainly have seen them because of the inherent contradiction if He refused. There is nothing wrong with such seeking. It is the duty of men to seek the Lord. Christ, on occasion, used such curiosity to draw men to Himself (as in the case of Zaccheus), and at other times left them to wonder unfulfilled (as in the case of Herod Philip).

It is interesting that Jesus does not see these "seekers".

(Verse 23) - "Hour" does not refer to to a specific moment, but to the general time of Christ's passion that, in other places, is said to not yet have come. It was often used to refer to a specific time that was definitely set in the counsels of God.

Note that Jesus refers to Himself as the "Son of Man". This is one of His favorite titles for Himself and speaks primarily to His coming representation of the children of God at the cross and before God. The title is used here precisely to underscore the substitutionary work He was about to undertake on behalf of the sheep. He would act to pay for the sins of the sheep and represent them before the bar of God's justice. It is a very beautiful and descriptive title.

"Be Glorified" it a particularly interesting way for Christ to refer to His coming passion. Many see this as a reference to His resurrection and ascension. But I think it refers to the dying of the death of the cross and the definite achievement of the salvation of believers. This was the single most glorifying act to the Father in all of human history.

(Verse 24) - That His statement refers to His death and all that accompanied it is borne out by this next verse. The analogy of the grain dying is a direct reference to this "glory".

(Verse 25) - We should just like to note that the frequent commendation by Christ to His followers to despise themselves was one that He followed Himself. 

How do those facts apply to my life?:

 Any and all are commanded and invited to come to Christ.  I must keep this in mind as I seek to share the Gospel.  The "target audience" that God has for me is broad - it includes everyone I come in contact with!  We should be seeking to share the Gospel with any and all who we come in contact with.